发给老马备查:: b5 D; u* h% g9 F
滴水察海(69304838) 15:23:23
0 Q) V# g1 {8 e4 P! s, r老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
( V+ F( \4 R$ R. I吉非替尼和S-1连用的依据
, c6 t& F, F* e, x& ^! V1 d% IGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' a1 t6 p% k7 b2 y- h是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达+ g5 q! j# Z5 R/ q6 t4 d9 N1 W
这样是不是推理出,耐药后,可以用S-1和培美了?! p2 L, D" ]* h( [- p1 ~4 R f
结论:' d, Y) |0 g. R
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |