发给老马备查:# c7 ]; h1 E9 X( \2 G+ H' ]: C q
滴水察海(69304838) 15:23:23
3 K6 u2 P9 z! V( G4 c老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱7 ?! ]+ B G4 O d. o
吉非替尼和S-1连用的依据
( s2 Z/ ^$ M7 F' s) P4 {4 YGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.+ n7 G% [2 H/ r$ ^# O5 v3 X m; W
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达/ ?2 v2 ~9 T! G
这样是不是推理出,耐药后,可以用S-1和培美了?: y9 v, @& L. O- a3 g5 l
结论:
; C6 ~4 _: K: v& m" S; `# j如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |