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) V0 o, E) j3 s g% M T健择(吉西他滨)+顺铂+阿瓦斯汀
" o7 m- a: w2 I7 B4 p4 N" ^2 \0 | Gemzar +Cisplatin + Avastin
0 N4 e9 @$ n( b0 fhttp://annonc.oxfordjournals.org/content/21/9/1804.full9 ?- r- K/ F, o8 Z& a( J9 N
Overall survival with cisplatin–gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
) v, n0 k* e/ B* h& r* sPatients and methods: Patients (n = 1043) received cisplatin 80 mg/m2 and gemcitabine 1250 mg/m2 for up to six cycles plus bevacizumab 7.5 mg/kg (n = 345), bevacizumab 15 mg/kg (n = 351) or placebo (n = 347) every 3 weeks until progression. Primary end point was progression-free survival (PFS); OS was a secondary end point.
$ D! v8 J) R/ J- n$ }9 K( P7 a& H9 gResults: Significant PFS prolongation with bevacizumab compared with placebo was maintained with longer follow-up {hazard ratio (HR) [95% confidence interval (CI)] 0.75 (0.64–0.87), P = 0.0003 and 0.85 (0.73–1.00), P = 0.0456} for the 7.5 and 15 mg/kg groups, respectively. Median OS was >13 months in all treatment groups; nevertheless, OS was not significantly increased with bevacizumab [HR (95% CI) 0.93 (0.78–1.11), P = 0.420 and 1.03 (0.86–1.23), P = 0.761] for the 7.5 and 15 mg/kg groups, respectively, versus placebo. Most patients (62%) received multiple lines of poststudy treatment. Updated safety results are consistent with those previously reported. 0 R! d8 A4 g6 U8 E$ M; p' P+ @
Cisplatin Gemzar Avastin.PDF
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