关于9291耐药之后C797S与T790m反式存在

弱智儿童向太阳 · 发表于 2016-1-26 16:05:33

弱智儿童向太阳发表于 2016-1-26 15:00
我就按照原文的翻译的，图里的tran标示翻译了一下

额？我就是按照结果的显示翻译的
Cells resistant to a third-generation TKI acquired an additional EGFR mutation, C797S, which prevented suppression of EGFR. Our results demonstrate that the allelic context in which C797S was acquired may predict responsiveness to alternative treatments. If the C797S and T790M mutations are in trans, cells will be resistant to third-generation EGFR TKIs, but will be sensitive to a combination of first- and third-generation TKIs. If the mutations are in cis, no EGFR TKIs alone or in combination can suppress activity. If C797S develops in cells wild-type for T790 (when third-generation TKIs are administered in the first-line setting), the cells are resistant to third-generation TKIs, but retain sensitivity to first-generation TKIs.

弱智儿童向太阳 · 发表于 2016-1-28 13:16:50

elexujx 发表于 2016-1-21 11:41
求指点。

1. 图显示3个等位基因。是否提示EGFR（HER1）有可能是复等位基因？

1.我觉得这种提示还没有证据；2，应该是杂合子，据我记得以前学过的，纯合子应该是没有等位基因的， D-d这种属于等位基因，而DDdd这种属于相同基因，我记得是这样的，嘻嘻 3. 我觉得致癌突变并不一定会导致癌症，要看是不是驱动基因的吧；4. 图上看是您说的这样，顺式其实就是同侧，反式就是异侧，在化学里化学键的描述是这样的，我觉得遗传上应该也如； 5这点我也不是很清楚，信号转导的问题我也很晕。