看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。
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Currently available feasibility data for possible combination strategies.
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- P/ O* k7 U0 W; }Combination Feasibility according to preliminary data . T' D0 Y: z' c2 ~2 U: }
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Bevacizumab + sorafenib Yes, reduced dose r4 n9 o7 z6 W0 b, U- X
Bevacizumab + sunitinib† No / K# w% C$ Q. i9 ?" a
Bevacizumab + temsirolimus Yes
" c" z8 S ~9 ^2 x/ EBevacizumab + everolimus Yes # [5 {0 y$ r$ e& p, m2 D; S6 p
Sorafenib + sunitinib ?
. B2 L- d7 h9 n6 S2 ~3 c9 Z4 S6 H( t7 PSorafenib + temsirolimus Yes, reduced dose 5 k( }4 j6 N2 N1 w1 b$ k
Sorafenib + everolimus Yes, reduced dose 8 f' R J% W* k/ }4 V, `' a
Sunitinib + temsirolimus† No 5 W7 J& z7 Z7 d0 r
Sunitinib + everolimus ? 1 Q/ V) h p7 i& V! H* e
Temsirolimus + everolimus ? # n3 G# {) Q/ ~/ c* ` q
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†Led to US FDA warning.
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